解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Sustainable food production in the context of climate change necessitates diversification of agriculture and a more efficient utilization of plant genetic resources. Fonio millet (Digitaria exilis) is an orphan African cereal crop with a great potential for dryland agriculture. Here, we establish high-quality genomic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18329-4
更新日期:2020-09-08 00:00:00
abstract::Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18200-6
更新日期:2020-09-07 00:00:00
abstract::Traditionally, molecular assembly pathways for viruses are inferred from high resolution structures of purified stable intermediates, low resolution images of cell sections and genetic approaches. Here, we directly visualise an unsuspected 'single shelled' intermediate for a mammalian orthoreovirus in cryo-preserved i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18243-9
更新日期:2020-09-07 00:00:00
abstract::Atropisomers are important organic frameworks in bioactive natural products, drugs as well as chiral catalysts. Meanwhile, silanols display unique properties compared to their alcohol analogs, however, the catalytic synthesis of atropisomers bearing silanol groups is challenging. Here, we show a rhodium-catalyzed tors...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18273-3
更新日期:2020-09-07 00:00:00
abstract::The lattice dynamics and high-temperature structural transition in SnS and SnSe are investigated via inelastic neutron scattering, high-resolution Raman spectroscopy and anharmonic first-principles simulations. We uncover a spectacular, extreme softening and reconstruction of an entire manifold of low-energy acoustic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18121-4
更新日期:2020-09-04 00:00:00
abstract::Quantum states induced by single-atomic impurities are at the frontier of physics and material science. While such states have been reported in high-temperature superconductors and dilute magnetic semiconductors, they are unexplored in topological magnets which can feature spin-orbit tunability. Here we use spin-polar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18111-6
更新日期:2020-09-04 00:00:00
abstract::The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and genetically targeted approaches we have confirmed an indispensable role for vasoactive intestinal polypeptide-expressing SCN (SCNVIP) neurons, i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17197-2
更新日期:2020-09-02 00:00:00
abstract::Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system is de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18238-6
更新日期:2020-09-02 00:00:00
abstract::Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these im...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18138-9
更新日期:2020-09-01 00:00:00
abstract::The Amazon river basin receives ~2000 mm of precipitation annually and contributes ~17% of global river freshwater input to the oceans; its hydroclimatic variations can exert profound impacts on the marine ecosystem in the Amazon plume region (APR) and have potential far-reaching influences on hydroclimate over the tr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18187-0
更新日期:2020-09-01 00:00:00
abstract::The successful mitigation of emerging wildlife diseases may involve controversial host culling. For livestock, 'preemptive host culling' is an accepted practice involving the removal of herds with known contact to infected populations. When applied to wildlife, this proactive approach comes in conflict with biodiversi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18229-7
更新日期:2020-09-01 00:00:00
abstract::Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits of the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18068-6
更新日期:2020-08-28 00:00:00
abstract::The interpretation of molecular vibrational spectroscopic signals in terms of atomic motion is essential to understand molecular mechanisms and for chemical characterization. The signals are usually assigned after harmonic normal mode analysis, even if molecular vibrations are known to be anharmonic. Here we obtain th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18211-3
更新日期:2020-08-28 00:00:00
abstract::Scintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18119-y
更新日期:2020-08-28 00:00:00
abstract::A common analysis of single-cell sequencing data includes clustering of cells and identifying differentially expressed genes (DEGs). How cell clusters are defined has important consequences for downstream analyses and the interpretation of results, but is often not straightforward. To address this difficulty, we prese...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17900-3
更新日期:2020-08-28 00:00:00
abstract::Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18208-y
更新日期:2020-08-28 00:00:00
abstract::Tuning the thermodynamic state of a material has a tremendous impact on its performance. In the case of polymers placed in proximity of a solid wall, this is possible by annealing above the glass transition temperature, Tg, which induces the formation of an adsorbed layer. Whether heating to higher temperatures would ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18216-y
更新日期:2020-08-28 00:00:00
abstract::Plant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17949-0
更新日期:2020-08-27 00:00:00
abstract::'Ideal' transparent p-type semiconductors are required for the integration of high-performance thin-film transistors (TFTs) and circuits. Although CuI has recently attracted attention owing to its excellent opto-electrical properties, solution processability, and low-temperature synthesis, the uncontrolled copper vaca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18006-6
更新日期:2020-08-27 00:00:00
abstract::Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective cohort of 491 active surveillance (AS) participants indicates prominent elevations in plasma sphingolipids in AS progressors that, together wi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17645-z
更新日期:2020-08-27 00:00:00
abstract::Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of AAA and accelerates macrophage-driven prote...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18088-2
更新日期:2020-08-27 00:00:00
abstract::Mangrove forests hold some of the highest densities of carbon recorded in any ecosystem, but have experienced widespread deforestation through conversion to aquaculture and agriculture. Alongside deforestation, mangroves have shown simultaneous natural expansion in some parts of the world, and considerable investments...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18118-z
更新日期:2020-08-26 00:00:00
abstract::Acute stroke causes complex, pathological, and systemic responses that have not been treatable by any single medication. In this study, using a murine transient middle cerebral artery occlusion stroke model, a novel therapeutic strategy is proposed, where blood replacement (BR) robustly reduces infarctions and improve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17930-x
更新日期:2020-08-25 00:00:00
abstract::How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18075-7
更新日期:2020-08-25 00:00:00
abstract::Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equivalent ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18000-y
更新日期:2020-08-25 00:00:00
abstract::Surface plasmons (SPs) of metals enable the tight focusing and strong absorption of light to realize an efficient utilization of photons at nanoscale. In particular, the SP-generated hot carriers have emerged as a promising way to efficiently drive photochemical and photoelectric processes under moderate conditions. I...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18016-4
更新日期:2020-08-24 00:00:00
abstract::Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs. The genetic tools available for engineering intercellular signaling, however, are quite limited. Here we exploit the chemical diversity of biological small molecules to de novo design ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17993-w
更新日期:2020-08-24 00:00:00
abstract::As a key variance partitioning tool, linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML) allow both fixed and random effects. Classic LMMs assume independence between random effects, which can be violated, causing bias. Here we introduce a generalized GREML, named CORE GREML, that expli...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18085-5
更新日期:2020-08-21 00:00:00
abstract::Antibiotic biosynthetic gene clusters (BGCs) produce bioactive metabolites that impart a fitness advantage to their producer, providing a mechanism for natural selection. This selection drives antibiotic evolution and adapts BGCs for expression in different organisms, potentially providing clues to improve heterologou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18018-2
更新日期:2020-08-21 00:00:00
abstract::Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in the development of optimized small-molecule compounds. Current approaches cannot identify the protein targets of a compound and also detect the interaction s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18071-x
更新日期:2020-08-21 00:00:00
abstract::The need for active and stable oxidation catalysts is driven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and energy sustainability. Traditional approaches focus on oxygen-activating oxides as support which provides the oxygen activation at the catalyst-support peripheral i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18017-3
更新日期:2020-08-21 00:00:00
abstract::Charge acceleration during an intense light field application to solids attracts much attention as elementary processes in high-harmonic generation and photoelectron emission. For manipulating such attosecond dynamics of charge, carrier-envelope-phase (CEP: relative phase between carrier oscillation of light field and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17776-3
更新日期:2020-08-18 00:00:00
abstract::Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry, and between cells to form polykaryocytes in infected tissues. The conserved glycoproteins, gB, gH and gL, are the core functional protein...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17911-0
更新日期:2020-08-18 00:00:00
abstract::1T-MoS2 and single-atom modified analogues represent a highly promising class of low-cost catalysts for hydrogen evolution reaction (HER). However, the role of single atoms, either as active species or promoters, remains vague despite its essentiality toward more efficient HER. In this work, we report the unambiguous ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17904-z
更新日期:2020-08-17 00:00:00
abstract::Kilonovae produced by the coalescence of compact binaries with at least one neutron star are promising standard sirens for an independent measurement of the Hubble constant (H0). Through their detection via follow-up of gravitational-wave (GW), short gamma-ray bursts (sGRBs) or optical surveys, a large sample of kilon...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17998-5
更新日期:2020-08-17 00:00:00
abstract::Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by HGPS-S...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17901-2
更新日期:2020-08-17 00:00:00
abstract::Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of proviral integration sites. However, the source of the proliferation of HIV-infected cells remains unclear. Here, we analyze the TCR repertoire of single HIV-infected cells harboring translation-competent proviruses in longitudinal ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17898-8
更新日期:2020-08-14 00:00:00
abstract::Replicating biological patterns is promising for designing materials with multifaceted properties. Twisted cholesteric liquid crystal patterns are found in the iridescent tessellated cuticles of many insects and a few fruits. Their accurate replication is extremely difficult since discontinuous patterns and colors mus...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17884-0
更新日期:2020-08-14 00:00:00
abstract::Tomatoes come in a multitude of shapes and flavors despite a narrow genetic pool. Here, we leverage whole-genome resequencing data available for 602 cultivated and wild accessions to determine the contribution of transposable elements (TEs) to tomato diversity. We identify 6,906 TE insertions polymorphisms (TIPs), whi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17874-2
更新日期:2020-08-13 00:00:00
abstract::Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficien...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17783-4
更新日期:2020-08-13 00:00:00